Is Glaxo’s $5bn cancer investment about to pay off?

Another successful drug trial may have GlaxoSmithKline plc (LON: GSK) shares on the rise.

The content of this article was relevant at the time of publishing. Circumstances change continuously and caution should therefore be exercised when relying upon any content contained within this article.

When investing, your capital is at risk. The value of your investments can go down as well as up and you may get back less than you put in.

Read More

The content of this article is provided for information purposes only and is not intended to be, nor does it constitute, any form of personal advice. Investments in a currency other than sterling are exposed to currency exchange risk. Currency exchange rates are constantly changing, which may affect the value of the investment in sterling terms. You could lose money in sterling even if the stock price rises in the currency of origin. Stocks listed on overseas exchanges may be subject to additional dealing and exchange rate charges, and may have other tax implications, and may not provide the same, or any, regulatory protection as in the UK.

You’re reading a free article with opinions that may differ from The Motley Fool’s Premium Investing Services. Become a Motley Fool member today to get instant access to our top analyst recommendations, in-depth research, investing resources, and more. Learn More.

Drug companies often have a strange relationship with investors, and the public more broadly. On the one hand, they are simply companies trying to make a profit, increasing shareholder value, as any good company should. On the other hand, and I believe a far more important one, they are creating vaccines and treatments that can change the face of medicine and save lives.

This week, GlaxoSmithKline (LSE: GSK) announced the success of a cancer drug (that it acquired in a controversial deal at the end of last year) in stopping the spread of ovarian cancer – a disease that impacts about 300,000 women a year.

Controversial purchase

In its first major acquisition under new CEO Emma Walmsley, the $5.1bn purchase of the US biotech firm Tesaro caused some concerns for investors when it was announced in December 2018. GSK was paying a massive 200% premium for the shares, the cost being such a hit that it wiped about £5bn from Glaxo’s market value the day it was announced.

The purchase was taken as a move for Glaxo into a class of drugs know as PARP inhibitors – Tesaro’s flagship drug Zejula being seen as the main target of the purchase. GSK said at the time that it believed it could build on the drug’s success, and saw potential to expand the number of women this treatment may be able to help.

One of the main investor concerns surrounding the acquisition, aside from the expense itself, is that the Zejula treatment has fierce competition, particularly from AstraZeneca’s Lynparza drug. This competition was already causing large volatility in Tesaro’s share price and remains, to some extent, a cloud over the commercial aspects of the treatment.

Making money, saving lives

Currently only about 15% of women who suffer from ovarian cancer have a particular gene mutation that allows this PARP inhibitor treatment to be effective. These latest results, according to GSK’s Chief Scientific Officer Hal Barron, “demonstrate that Zejula has the potential to significantly benefit even more women with this devastating cancer”. This once again seems to be an example of Big Pharma making money by saving lives.

But is this enough to make Glaxo a good investment?

Not in its own right, perhaps, but taken in context, I think there are definitely some good signs. The news certainly seems to suggest the large acquisition was a smart move on the part of management, something always worth considering in a potential investment. Meanwhile, its latest quarterly results also showed some decent numbers, including increased sales, higher earnings and a number of successes with the money its current treatments are bringing in.

As with all the large pharmaceutical companies, there are concerns over the increasing market for cheaper, generic medications. Glaxo specifically said its asthma drug Advair is likely to see sales falling after a cheaper generic alternative was recently approved by the FDA.

I think even taking this into account however, there are some positive indications that GSK’s share price has room to move up — most notably its partnership with Pfizer, which has the two companies pooling their research and development for the treatment of HIV. With a current dividend yield just under the 5% mark, Glaxo is certainly going to be one I keep my eye on.

Should you invest, the value of your investment may rise or fall and your capital is at risk. Before investing, your individual circumstances should be assessed. Consider taking independent financial advice.

Karl has no positions in any of the shares mentioned. The Motley Fool UK owns shares of and has recommended GlaxoSmithKline. Views expressed on the companies mentioned in this article are those of the writer and therefore may differ from the official recommendations we make in our subscription services such as Share Advisor, Hidden Winners and Pro. Here at The Motley Fool we believe that considering a diverse range of insights makes us better investors.

More on Investing Articles

Investing Articles

“The biggest lesson I’ve learned from the stock market in 2024 has been…”

Stock-market investing is subject to ups and downs (but, historically, ups overall!) What are you taking away from this year?

Read more »

Bearded man writing on notepad in front of computer
Investing Articles

Could a 2025 penny share takeover boom herald big profits for investors?

When penny share owners get caught up in a takeover battle, what might happen? Christopher Ruane looks at some potential…

Read more »

Young woman working at modern office. Technical price graph and indicator, red and green candlestick chart and stock trading computer screen background.
Investing Articles

3 value shares for investors to consider buying in 2025

Some value shares blew the roof off during 2024, so here are three promising candidates for investors to consider next…

Read more »

Investing Articles

Can this takeover news give Aviva shares the boost we’ve been waiting for?

Aviva shares barely move as news of the agreed takeover of Direct Line emerges. Shareholders might not see it as…

Read more »

Investing Articles

2 cheap FTSE 250 growth shares to consider in 2025!

These FTSE 250 shares have excellent long-term investment potential, says Royston Wild. Here's why he thinks they might also be…

Read more »

A pastel colored growing graph with rising rocket.
Investing Articles

Has the 2024 Scottish Mortgage share price rise gone under the radar?

The Scottish Mortgage share price rise has meant a good year for the trust so far, but not as good…

Read more »

Investing Articles

Will the easyJet share price hit £10 in 2025?

easyJet has been trading well with rising earnings, which reflects in the elevated share price, but there may be more…

Read more »

Investing Articles

2 FTSE shares I won’t touch with a bargepole in 2025

The FTSE 100 and the FTSE 250 have some quality stocks. But there are others that Stephen Wright thinks he…

Read more »