Which is Your Best Pharma Bet: GlaxoSmithKline plc, AstraZeneca plc Or Shire PLC?

G A Chester puts GlaxoSmithKline plc (LON:GSK), AstraZeneca plc (LON:AZN) and Shire PLC (LON:SHP) under the spotlight.

| More on:

The content of this article was relevant at the time of publishing. Circumstances change continuously and caution should therefore be exercised when relying upon any content contained within this article.

You’re reading a free article with opinions that may differ from The Motley Fool’s Premium Investing Services. Become a Motley Fool member today to get instant access to our top analyst recommendations, in-depth research, investing resources, and more. Learn More.

The mantra of expand and diversify seems to have gone rather out of fashion since the global financial crisis and recession. These days the rallying cry is: concentration and focus.

Just about everywhere you look, be it banks, miners or oil companies, you’ll have heard chief executives talking about selling “non-core” assets, and pulling out of this territory or that line of business.

It’s been happening in the pharmaceuticals industry, too. The top three FTSE 100 pharma groups — GlaxoSmithKline (LSE: GSK), AstraZeneca (LSE: AZN) and Shire (LSE: SHP) — have been as busy “de-complexifying” as anyone else.

Glaxo has been in restructuring mode for what seems like forever. We’ve seen — among other things — the sale of its consumer drinks brands Lucozade and Ribena, the disposal of its oncology business, and the shifting of its consumer healthcare business into a joint venture.

Meanwhile, Astra’s recent divestment of a gastroenterology medicine is just the latest in a long line of actions designed to narrow down the company’s “strategic focus on selected therapy areas”, notably cancer, diabetes and respiratory medicines.

And Shire has been at it, too. Peripheral stuff — such as skin substitute Dermagraft — has gone, as part of the company’s “sharpened strategic focus” on core therapy areas in rare diseases and other specialty conditions.

As well as divesting non-core products and businesses, all three companies have been buying assets that complement and strengthen their chosen areas of focus.

Which pharma firm now offers investors the best prospects going forward? Well, all three companies have given guidance on their sales targets for some way ahead.

  • Shire: 10% compound annual growth rate (CAGR) — not including M&A and in-licensing — to deliver sales of $10bn (£6.45bn at current exchange rates) by 2020.
  • Astra: sales of $45bn by 2023 (the implied CAGR giving sales of $36bn — £23.2bn at current exchange rates — by 2020).
  • Glaxo: “low-to-mid single digits” CAGR to 2020 (a 4.5% CAGR would get sales to £30bn by 2020).

If the three companies maintained their current price-to-sales ratings in 2020, the table below shows what would happen (based on current number of shares in issue).

  Market cap today Market cap 2020 Share price today Share price 2020 Increase in share price
Shire £33.1bn £50.8bn £56 £86 54%
Astra £54.3bn £75.9bn £43 £60 40%
Glaxo £65.7bn £81.9bn £13.5 £17 26%

Of course, in addition to my mooted increases in share prices, there are dividends to consider. Current yields vary widely: Shire at 0.3%, Astra at 4.2% and Glaxo at 5.9%.

I calculate that Shire could deliver a total of £1.25 in dividends through to 2020, bumping up its return to 56%, Astra £9.5 for a 62% return and Glaxo £4.25 for a return of 57%.

All sorts of things could happen in the next five years, of course, but the close grouping of the returns thrown up by my sums, suggests the market is pricing the three companies very similarly, taking into account management sales growth targets plus the dividend return.

If there’s not much to choose between the companies’ valuations, are they — as a group — good value, poor value or fair value?

Shire’s shares have made record highs this year, and trade above the valuation of £53 or so put upon the company by US group AbbVie a year ago. But things have moved on since then — notably with Shire’s $5.2bn acquisition of NPS Pharmaceuticals — and I believe Shire is worth considerable more today. The company released strong half-year results yesterday, and City analysts have 12-month price targets of £60+.

Meanwhile, Astra’s shares are currently 22% down from a rejected £55 offer made by Pfizer last year, and Glaxo’s shares are 18% down from their 52-week high.

As such, I reckon all three companies are very buyable at their current levels. Income seekers may find Glaxo particularly attractive with its high yield, Astra has strong growth & income credentials, while Shire has much to offer growth investors.

G A Chester has no position in any shares mentioned. The Motley Fool UK has recommended GlaxoSmithKline. We Fools don't all hold the same opinions, but we all believe that considering a diverse range of insights makes us better investors.

More on Investing Articles

This way, That way, The other way - pointing in different directions
Investing Articles

As the FTSE indexes sink, these unique dividend shares are making investors money

These two dividend shares are in positive territory for the month and outperforming the major FTSE indexes by a significant…

Read more »

Rolls-Royce's Pearl 10X engine series
Investing Articles

Down 15% in days, are Rolls-Royce shares suddenly a bargain again?

Rolls-Royce shares have been heading south over the past couple of weeks. This writer thinks that makes sense -- but…

Read more »

Woman riding her old fashioned bicycle along the Beach Esplanade at Aberdeen, Scotland.
Investing Articles

What would a 40-year-old need to put into an empty SIPP to target monthly passive income of £1,000?

From a standing start at 40, how might someone target a four-figure monthly income stream from their SIPP? Christopher Ruane…

Read more »

British flag, Big Ben, Houses of Parliament and British flag composition
Investing Articles

As the ISA deadline approaches, UK investors have the opportunity to buy cheap shares

In recent weeks, equity markets have fallen significantly due to the conflict in the Middle East. As a result, many…

Read more »

Array of piggy banks in saturated colours on high colour contrast background
Investing Articles

£5k left in a Stocks and Shares ISA? 2 top ETFs to consider buying in April

Ben McPoland highlights a pair of very different ETFs that he thinks could help generate long-term wealth inside an ISA…

Read more »

Two business people sitting at cafe working on new project using laptop. Young businesswoman taking notes and businessman working on laptop computer.
Investing Articles

Could a £20,000 ISA end up generating £20,000 of passive income each year?

Could a Stocks and Shares ISA ultimately cover its own cost each year with the passive income it produces? Christopher…

Read more »

A young black man makes the symbol of a peace sign with two fingers
Investing Articles

2 top stocks to consider buying after this week’s FTSE carnage

Investors looking for beaten-up stocks to buy for the long term have a lot of great options after the recent…

Read more »

Smart young brown businesswoman working from home on a laptop
Investing Articles

A stock market crash could be a gift for long-term investors

A stock market crash could present some outstanding buying opportunities. But the key to taking advantage is knowing what to…

Read more »